Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Mult Scler Relat Disord. 2018 Jan;19:70-72. doi: 10.1016/j.msard.2017.11.009. Epub 2017 Nov 8.
NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.
NMOSD 主要发生在育龄期女性中，既往多项研究表明该疾病可能增加流产风险。然而，据我们所知，尚无 NMOSD 导致胎儿畸形（除新生儿脑积水外）的报道。我们报告了 1 例 30 岁女性，其反复发生神经炎且血清抗水通道蛋白 4 抗体（AQP4-IgG）阳性，该患者妊娠后发现胎儿存在并指畸形。胎盘组织学分析显示中度炎症浸润；然而，NMOSD 中的胎儿畸形是否与炎症和 AQP4-IgG 有关仍有待确定。
