Yaguchi Hiroaki, Mito Yasunori, Ohashi Ikkei, Nomura Taichi, Yabe Ichiro, Tajima Yasutaka
Department of Neurology, Brain Science Center, Sapporo City General Hospital, Japan.
Department of Neurology, Hokkaido University Graduate School of Medicine, Japan.
Intern Med. 2017;56(13):1729-1732. doi: 10.2169/internalmedicine.56.7889. Epub 2017 Jul 1.
The patient was a woman without hypertension who had previously experienced intracranial hemorrhage twice at 48 and 56 years of age. At 59 years of age, she was diagnosed with neuromyelitis optica spectrum disorder (NMOSD) based on the presence of a brain stem lesion and the detection of anti-aquaporin 4 (AQP4) antibodies. After 5 months of continuous treatment with prednisolone (15 mg/day), she presented with optic neuritis and intracranial bleeding. A recurrent attack of NMOSD and intracranial hemorrhage were concurrently diagnosed. We herein report a case of NMOSD with recurrent intracranial hemorrhage, which indicates an association between NMOSD and cerebellar vascular dysfunction.
该患者为一名无高血压病史的女性，曾在48岁和56岁时两次发生颅内出血。59岁时，基于脑干病变的存在以及抗水通道蛋白4（AQP4）抗体的检测，她被诊断为视神经脊髓炎谱系障碍（NMOSD）。在接受泼尼松龙（15毫克/天）持续治疗5个月后，她出现了视神经炎和颅内出血。同时诊断出NMOSD复发和颅内出血。我们在此报告一例伴有复发性颅内出血的NMOSD病例，这表明NMOSD与小脑血管功能障碍之间存在关联。
