Selmi Carlo, Generali Elena, Gershwin Merrill Eric
Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, Rozzano, Milan 20089, Italy; BIOMETRA Department, University of Milan, Via Luigi Vanvitelli, 32, 20129 Milano, MI, Italy.
Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, Rozzano, Milan 20089, Italy.
Rheum Dis Clin North Am. 2018 Feb;44(1):65-87. doi: 10.1016/j.rdc.2017.09.008.
Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti-liver kidney microsomal antibodies (AIH). Therapeutic strategies may overlap between rheumatic and autoimmune liver diseases and practitioners should be vigilant in managing bone loss.
自身免疫性肝病在约30%的病例中与风湿性疾病共存，并且可能具有共同的致病机制。自身免疫性肝病是由不同组织的免疫介导损伤引起的，自身免疫性肝炎（AIH）以肝细胞为靶点，原发性胆汁性胆管炎（PBC）和原发性硬化性胆管炎以胆管细胞为靶点。干燥综合征在7%的AIH病例中被诊断出来，血清学自身免疫谱是常见的实验室异常，特别是在血清抗线粒体抗体（PBC）或抗肝肾微粒体抗体（AIH）的情况下。风湿性疾病和自身免疫性肝病的治疗策略可能重叠，从业者在管理骨质流失方面应保持警惕。
