Capriolli Tiago Verri, Visentainer Jeane Eliete Laguila, Sell Ana Maria
Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil.
Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil.
Rev Bras Hematol Hemoter. 2017 Oct-Dec;39(4):301-305. doi: 10.1016/j.bjhh.2017.05.007. Epub 2017 Jun 28.
The Kidd blood group system has three antigens, Jk, Jk and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(a-b-) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease.
Jk and Jk antigens were phenotyped using the gel column agglutination test (ID-cards Bio-RAD) in 197 patients with chronic kidney disease and 444 blood donors, as the control group. The phenotype and antigen frequencies between patients and controls were evaluated using the Chi-square method with Yates correction and logistic regression after adjustments for gender and age.
No differences were observed between the Kidd phenotypes frequency distribution between patients with chronic kidney disease and blood donors [Jk(a-b+)=22.3% and 27.2%; Jk(a+b-)=30.5% and 24.3%; Jk(a+b+)=47.25% and 48.4%, respectively].
The distribution of Kidd phenotypes found in the studied population is expected for Caucasians; Jk and Jk antigens and phenotypes were not found to be related to susceptibility for chronic kidney disease.
基德血型系统有三种抗原，即Jk、Jk和Jk3，存在于红细胞以及肾髓质血管内衬的内皮细胞上。这些抗原被称为尿素转运蛋白B（UT-B）。研究人员发现，携带Jk(a-b-)或Jk缺失（UT-B缺失）表型的个体尿液浓缩能力较低，且有严重肾功能损害的风险。本研究评估了慢性肾脏病患者中基德表型的分布情况以及基德抗原与肾脏疾病发生之间可能存在的关联。
采用凝胶柱凝集试验（ID卡，伯乐公司）对197例慢性肾脏病患者和444名献血者（作为对照组）进行Jk和Jk抗原表型分析。采用校正Yates的卡方检验以及在对性别和年龄进行校正后的逻辑回归分析，评估患者与对照组之间的表型和抗原频率。
慢性肾脏病患者与献血者的基德表型频率分布未观察到差异[Jk(a-b+)=22.3%和27.2%；Jk(a+b-)=30.5%和24.3%；Jk(a+b+)=47.25%和48.4%，分别]。
在研究人群中发现的基德表型分布符合白种人的预期情况；未发现Jk和Jk抗原及表型与慢性肾脏病易感性相关。
