Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires, Argentina.
Department of Ophthalmology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Med Hypotheses. 2017 Nov;109:156-161. doi: 10.1016/j.mehy.2017.10.001. Epub 2017 Oct 13.
Age-related macular disease (AMD) and diabetic retinopathy (DR) are prevalent diseases. Vascular endothelial growth factor (VEGF) related retinal neovascularization is a common feature in both. Consequently, both pathologies are treated with anti-VEGF therapy. We have previously reported a lower incidence of AMD in patients with DR compared to controls. The present study hypothesizes that DR in stages in which the concentration of intravitreal VEGF is increased, might have a protective role for both the onset and development of AMD.
年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变（DR）是常见疾病。血管内皮生长因子（VEGF）相关的视网膜新生血管是两者的共同特征。因此，两种病变都采用抗 VEGF 治疗。我们之前的报告显示，与对照组相比，DR 患者 AMD 的发病率较低。本研究假设，在 VEGF 浓度升高的 DR 阶段，可能对 AMD 的发生和发展具有保护作用。
