视网膜色素上皮和 Müller 细胞分泌组在新生血管性视网膜病变中的作用。
The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies.
机构信息
CEDOC - Chronic Diseases Center, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal; Bioengineering-Cell Therapies and Regenerative Medicine PhD Program, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
CEDOC - Chronic Diseases Center, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal; ProRegeM - PhD Programme Mechanisms of Disease and Regenerative Medicine, NOVA Medical School, Universidade NOVA de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
出版信息
Biochimie. 2018 Dec;155:104-108. doi: 10.1016/j.biochi.2018.06.019. Epub 2018 Jun 28.
Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.
分泌的营养因子对于维持视网膜的结构和功能完整性至关重要，因为它们调节着细胞通路，而这些细胞通路负责细胞的存活、功能以及对损伤的反应。然而，由于细胞分泌功能受损，这些相同的因子也可能参与视网膜病变。被认为是视网膜分泌组主要贡献者的细胞是视网膜色素上皮（RPE）和 Müller 细胞。在本文简短的综述中强调了它们在视网膜中最常见的新生血管病变（年龄相关性黄斑变性（AMD）、糖尿病性视网膜病变（DR）和早产儿视网膜病变（ROP））的病理生理学中的作用，以及当前基于营养因子的治疗方法，这些方法主要侧重于控制炎症、细胞存活和血管生成。
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