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转换障碍、做作性障碍和诈病:一种独特模式还是一个连续体?

Conversion, Factitious Disorder and Malingering: A Distinct Pattern or a Continuum?

作者信息

Galli Silvio, Tatu Laurent, Bogousslavsky Julien, Aybek Selma

出版信息

Front Neurol Neurosci. 2018;42:72-80. doi: 10.1159/000475699. Epub 2017 Nov 17.

Abstract

This chapter is aimed at highlighting the recent findings concerning physiopathology, diagnosis, and management of conversion, factitious disorder, and malingering. Conversion disorder is the unintentional production of neurological symptom, whereas malingering and factitious disorder represent the voluntary production of symptoms with internal or external incentives. They have a close history and this has been frequently confounded. Practitioners are often confronted to medically unexplained symptoms; they represent almost 30% of neurologist's consultation. The first challenge is to detect them, and recent studies have confirmed the importance of "positive" clinical bedside signs based on incoherence and discordance, such as the Hoover's sign for the diagnosis of conversion disorder. Functional neuroimaging has allowed a better understanding of the pathophysiology, and highlighted abnormal cerebral activation patterns in conversion disorder in relation to motor, emotional, and limbic networks, different from feigners. This supports the theory evoked by Charcot of a "psychodynamic lesion," which is also reflected by the new term introduced in the DSM-5: functional neurological disorder. Multidisciplinary therapy is recommended with behavioral cognitive therapy, antidepressant to treat frequent comorbid anxiety or depression, and physiotherapy. Factitious disorder and malingering should be clearly delineated from conversion disorder. Factitious disorder should be considered as a mental illness and more research on its physiopathology and treatment is needed, when malingering is a non-medical condition encountered in medico-legal cases.

摘要

本章旨在突出有关转换障碍、做作性障碍和诈病的病理生理学、诊断及管理方面的最新研究发现。转换障碍是神经系统症状的无意产生,而诈病和做作性障碍则代表有内在或外在动机的症状的故意产生。它们有着密切的渊源且常被混淆。从业者经常会遇到医学上无法解释的症状;这些症状在神经科医生的会诊病例中几乎占30%。首要挑战是识别它们,最近的研究证实了基于不连贯和不一致的“阳性”床边体征的重要性,比如用于诊断转换障碍的胡佛征。功能性神经影像学有助于更好地理解病理生理学,并突出了转换障碍中与运动、情感和边缘系统网络相关的异常脑激活模式,这与伪装者不同。这支持了夏科提出的“精神动力性损害”理论,这也反映在《精神疾病诊断与统计手册》第5版引入的新术语中:功能性神经障碍。建议采用多学科治疗,包括行为认知疗法、用于治疗常见共病焦虑或抑郁的抗抑郁药以及物理治疗。必须将做作性障碍和诈病与转换障碍明确区分开来。做作性障碍应被视为一种精神疾病,需要对其病理生理学和治疗进行更多研究,而诈病是在法医学案件中遇到的一种非医学状况。

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