与t(8;21)/RUNX1-RUNX1T1重排相关的孤立性胰腺髓系肉瘤
Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement.
作者信息
Tokunaga Kenji, Yamamura Ayako, Ueno Shikiko, Kikukawa Yoshitaka, Yamaguchi Shunichiro, Hidaka Michihiro, Matsuno Naofumi, Kawaguchi Tatsuya, Matsuoka Masao, Okuno Yutaka
机构信息
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan.
Department of Hematology, National Hospital Organization Kumamoto Medical Center, Japan.
出版信息
Intern Med. 2018 Feb 15;57(4):563-568. doi: 10.2169/internalmedicine.8912-17. Epub 2017 Nov 20.
No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient.
目前尚未确立针对孤立性髓系肉瘤（IMS）的有效治疗方法，由于其发病率低且发展方式独特，尚未进行全面的基因检查。我们在此报告一名34岁患有胰腺IMS且伴有t(8;21)/RUNX1-RUNX1T1重排的男性患者。他接受了大剂量阿糖胞苷治疗，随后进行了异基因造血干细胞移植（allo-HSCT）。这是首例关于伴有t(8;21)的胰腺IMS的报告。正电子发射断层扫描/计算机断层扫描和基因研究对诊断很有用，allo-HSCT使该患者实现了完全缓解。
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