麻醉对自噬的影响。
Anesthetic effects on autophagy.
作者信息
Ye Fan, Zuo Zhi-Yi
机构信息
Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.
出版信息
Med Gas Res. 2017 Oct 17;7(3):204-211. doi: 10.4103/2045-9912.215751. eCollection 2017 Jul-Sep.
Abstract
Anesthetic agents provide patient comfort and optimize conditions for surgical and procedural interventions. These agents have been shown to modulate autophagy, which is a cellular mechanism that maintains tissue homeostasis by degrading and recycling excess, aged, or dysfunctional proteins. However, it is not always clear if upregulated autophagy is beneficial or harmful. This review assesses the anesthetic effects on autophagy. In the vast majority of studies, anesthetic modulation of autophagy is beneficial for cell survival.
摘要
麻醉剂可使患者感到舒适，并为手术和操作干预优化条件。这些药物已被证明可调节自噬，自噬是一种细胞机制，通过降解和循环利用多余、老化或功能失调的蛋白质来维持组织稳态。然而，自噬上调是有益还是有害并不总是很清楚。这篇综述评估了麻醉对自噬的影响。在绝大多数研究中，麻醉对自噬的调节有利于细胞存活。
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Int J Mol Sci. 2017 Feb 10;18(2):367. doi: 10.3390/ijms18020367.
2
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J Cell Mol Med. 2017 Mar;21(3):579-587. doi: 10.1111/jcmm.13003. Epub 2016 Nov 15.
3
Dose-dependent effects of sevoflurane exposure during early lifetime on apoptosis in hippocampus and neurocognitive outcomes in Sprague-Dawley rats.
Int J Physiol Pathophysiol Pharmacol. 2016 Sep 30;8(3):111-119. eCollection 2016.
4
Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus.
Med Sci Monit. 2016 May 20;22:1702-8. doi: 10.12659/msm.897765.
5
Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats.
PLoS One. 2016 Apr 25;11(4):e0153505. doi: 10.1371/journal.pone.0153505. eCollection 2016.
6
Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells.
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7
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Int J Mol Sci. 2016 Mar 3;17(3):332. doi: 10.3390/ijms17030332.
8
Learning, memory and synaptic plasticity in hippocampus in rats exposed to sevoflurane.
Int J Dev Neurosci. 2016 Feb;48:38-49. doi: 10.1016/j.ijdevneu.2015.11.001. Epub 2015 Dec 2.
9
The Function of Autophagy in Neurodegenerative Diseases.
Int J Mol Sci. 2015 Nov 9;16(11):26797-812. doi: 10.3390/ijms161125990.
10
Sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3K/Akt-mPTP pathway.
Brain Res. 2016 Jan 1;1630:25-37. doi: 10.1016/j.brainres.2015.10.050. Epub 2015 Nov 2.
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