肾上腺素和体外膜肺氧合在缺血性难治性心室颤动管理中的作用：一项猪的随机试验。

Role of epinephrine and extracorporeal membrane oxygenation in the management of ischemic refractory ventricular fibrillation: a randomized trial in pigs.

作者信息

Bartos Jason A, Voicu Sebastian, Matsuura Timothy R, Tsangaris Adamantios, Sideris Georgios, Oestreich Brett A, George Stephen A, Olson Matthew, Shekar Kadambari Chandra, Rees Jennifer N, Carlson Kathleen, Sebastian Pierre, McKnite Scott, Raveendran Ganesh, Aufderheide Tom P, Yannopoulos Demetris

机构信息

Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN.

Medical and Toxicological Intensive Care Unit, Université Paris Diderot, Sorbonne Paris Cité, APHP, Lariboisière Hospital, 2 rue Ambroise Paré, 75475 Paris, France.

出版信息

JACC Basic Transl Sci. 2017 Jun;2(3):244-253. doi: 10.1016/j.jacbts.2017.02.003. Epub 2017 Jun 21.

xtracorporeal membrane oxygenation (ECMO) is used in cardiopulmonary resuscitation (CPR) of refractory cardiac arrest. We used a 2×2 study design to compare ECMO versus CPR and epinephrine versus placebo in a porcine model of ischemic refractory ventricular fibrillation (VF). Pigs underwent 5 minutes of untreated VF, 10 minutes of CPR, and were randomized to receive epinephrine versus placebo for another 35 minutes. Animals were further randomized to LAD reperfusion at minute 45 with ongoing CPR versus veno-arterial ECMO cannulation at minute 45 of CPR and subsequent LAD reperfusion. Four-hour survival was improved with ECMO while epinephrine showed no effect.