Trivedi P, Hindmarsh P, Risteli J, Risteli L, Mowat A P, Brook C G
Department of Child Health, King's College Hospital, London, United Kingdom.
J Pediatr. 1989 Feb;114(2):225-30. doi: 10.1016/s0022-3476(89)80787-5.
The relationship between serum concentrations of the amino-terminal propeptide of type III procollagen (PIIINP) and growth was assessed in 307 healthy subjects and 82 children with disorders of growth (41 with insufficient growth hormone, 23 with short stature and normal endocrinologic studies, 18 with tall stature) by means of a recently developed, simplified PIIINP radioimmunoassay. The PIIINP value appeared to be related to height velocity; in healthy children of each sex, the pattern of change with age mirrored the shape of the standard height velocity curve; in children with disorders of growth, there was a statistical correlation (p less than 0.001) between PIIINP concentration and height velocity. However, measurement of serum PIIINP alone had no diagnostic value because there was considerable overlap of PIIINP values in children with growth hormone insufficiency, short stature, normal stature, and tall stature. The most appropriate application of PIIINP may be in the monitoring of prepubertal children receiving exogenous growth hormone therapy; in these patients, increases in height velocity were reflected by increases in PIIINP, and early increases in PIIINP may have predictive value.
通过一种最新开发的简化型III型前胶原氨基端前肽（PIIINP）放射免疫分析法，对307名健康受试者和82名生长障碍儿童（41名生长激素不足、23名身材矮小但内分泌学检查正常、18名身材高大）的血清PIIINP浓度与生长之间的关系进行了评估。PIIINP值似乎与身高增长速度有关；在各性别的健康儿童中，其随年龄的变化模式反映了标准身高增长速度曲线的形状；在生长障碍儿童中，PIIINP浓度与身高增长速度之间存在统计学相关性（p<0.001）。然而，仅检测血清PIIINP没有诊断价值，因为生长激素不足、身材矮小、身材正常和身材高大的儿童的PIIINP值有相当大的重叠。PIIINP最恰当的应用可能是在监测接受外源性生长激素治疗的青春期前儿童；在这些患者中，身高增长速度的增加反映在PIIINP的增加上，而PIIINP的早期增加可能具有预测价值。
