Suenaga Miyu, Tomiyasu Hirotaka, Watanabe Manabu, Ogawa Kotogo, Motegi Tomoki, Goto-Koshino Yuko, Ohno Koichi, Sugano Sumio, Skorupski Katherine A, Tsujimoto Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Vet J. 2017 Oct;228:18-21. doi: 10.1016/j.tvjl.2017.10.002. Epub 2017 Oct 8.
The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P<0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.
犬淋巴瘤化疗耐药性获得的分子机制尚未阐明。本研究的目的是通过全面分析基因表达谱（GEP）的变化来确定化疗耐药性的新分子机制。从10只处于化疗敏感和化疗耐药阶段的淋巴瘤犬身上获取肿瘤样本。在化疗耐药期间，与免疫反应和炎症反应相关的基因表达与化疗敏感阶段相比有所下降。此外，从7只化疗耐药性淋巴瘤犬中提取了11个表达有显著变化（P<0.05）的基因。需要进一步研究来探讨GEP中的这些变化与犬淋巴瘤化疗耐药性获得之间的关联。
