Maisel Alan S, Duran Jason M, Wettersten Nicholas
Division of Cardiovascular Medicine, VA San Diego Healthcare System 111-A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.
Department of Internal Medicine, UC San Diego, 200 West Arbor Drive, La Jolla, San Diego, CA 92103, USA.
Heart Fail Clin. 2018 Jan;14(1):13-25. doi: 10.1016/j.hfc.2017.08.002.
The natriuretic peptides play a vital role in normal physiology and as counter-regulatory hormones in heart failure (HF). Clinical assessment of their levels (for B-type natriuretic peptide [BNP], N-terminal proBNP, and the midregion of N-terminal pro-atrial natriuretic peptide) have become valuable tools in diagnosing patients with HF as well as risk stratifying and guiding therapy. Their roles have further expanded beyond HF to other cardiovascular conditions and for risk stratification in asymptomatic individuals. Understanding the clinical use of these hormones is vital to achieving their full potential.
利钠肽在正常生理学中发挥着至关重要的作用，并且作为心力衰竭（HF）中的反调节激素。对其水平（B型利钠肽[BNP]、N末端proBNP和N末端心钠素原中段）的临床评估已成为诊断HF患者以及进行风险分层和指导治疗的重要工具。它们的作用已进一步扩展，从HF领域延伸到其他心血管疾病，并用于无症状个体的风险分层。了解这些激素的临床应用对于充分发挥其潜力至关重要。
