MCP-1与CCR2单核苷酸多态性与结直肠癌患病率的关联。
An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence.
作者信息
Walczak Anna, Przybyłowska-Sygut Karolina, Sygut Andrzej, Cieślak Adrianna, Mik Michał, Dziki Łukasz, Dziki Adam, Majsterek Ireneusz
机构信息
Department of Clinical Chemistry and Biochemistry, Medical University of Łódź, Poland.
Department of General Surgery, Pabianice Medical Center, Poland.
出版信息
Pol Przegl Chir. 2017 Oct 31;89(5):1-5. doi: 10.5604/01.3001.0010.5246.
THE AIM OF THE STUDY
We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence.
MATERIAL AND METHODS
Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
RESULTS
W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism.
CONCLUSION
The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
研究目的
我们评估了-2518 A/G单核细胞趋化蛋白-1（MCP-1）以及190 G/A C-C趋化因子受体2（CCR2）多态性变体的存在与结直肠癌（CRC）发生之间的关联。
材料与方法
研究组由处于不同阶段的结直肠癌患者以及健康对照组成。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法确定基因型。
结果
我们观察到结直肠癌与-2518 A/G MCP-1单核苷酸多态性的GG基因型之间存在关联。未发现CRC与190 G/A CCR2多态性之间存在统计学上的显著相关性。
结论
本研究结果支持以下假设，即MCP-1基因多态性可能与结直肠癌的病因有关。
Zotero 插件