Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006, Paris, France.
Chem Soc Rev. 2018 Jan 22;47(2):514-532. doi: 10.1039/c7cs00550d.
For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.
首次综述了树状聚合物与天然产物和类似物联合作为抗癌剂的情况。这反映了药物输送系统（如树状聚合物）的发展，以应对癌症。在纳米医学中使用树状聚合物的最大优势是其具有高生物相容性、良好的水溶性，并且可以通过内吞作用进入体内，无论是包裹、络合还是共轭药物。为了开发作为纳米载体的纳米系统，以降低抗癌药物的固有毒性、减少药物副作用、提高治疗效果，从而提高患者的顺应性，这一策略近年来得到了加速发展。
