用于药物递送的多孔GdF:Er,Yb-COOH核壳结构双功能纳米粒子的合成
Synthesis of porous GdF:Er,Yb-COOH core-shell structured bi-functional nanoparticles for drug delivery.
作者信息
Peng Hongxia, Jundai Ouyang, Wen Jin, Peng Yangxi
机构信息
School of Materials Science and Engineering, Central South University, Changsha, 410083, Hunan Province, People's Republic of China.
Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, School of Material and Environmental Engineering, Hunan University of Humanities, Science and Technology, Lou'di 417000, People's Republic of China.
出版信息
IET Nanobiotechnol. 2017 Dec;11(8):1052-1058. doi: 10.1049/iet-nbt.2016.0209.
The authors synthesised porous GdF:Er,Yb-COOH core-shell structured bi-functional nanoparticles through a one-step hydrothermal route during which ethylene diamine tetraacetic acid) was bound to the surface of the nanoparticles. It has high up-conversion emission intensity for monitoring the drug release process and magnetisation saturation value (10.2 emu/g) for drug targeting under foreign magnetic fields. Moreover, porous GdF:Er,Yb as drug carriers with a high drug-loading efficiency. cis-Dichlorodiammineplatinum(II) (cisplatin, CDDP)-loaded GdF:Er,Yb nanoparticles (GdF:Er,Yb-CDDP) were characterised by the Fourier transform infrared spectra, and CDDP was loaded in the form of electrostatic interaction and hydrogen bonds. Compared with CDDP alone, GdF:Er,Yb-CDDP nanoparticles increase concentration of CDDP in the target site and enhance its anticancer efficiency. Therefore, the as-prepared GdF:Er,Yb-COOH nanoparticles allow simultaneous targeted drug delivery and monitoring as promising anti-cancer theranostic agents.
作者通过一步水热法合成了具有多孔结构的GdF:Er,Yb-COOH核壳结构双功能纳米粒子，在此过程中乙二胺四乙酸被结合到纳米粒子表面。它具有高的上转换发射强度用于监测药物释放过程，以及在外部磁场下用于药物靶向的磁化饱和度值（10.2 emu/g）。此外，多孔GdF:Er,Yb作为药物载体具有高载药效率。通过傅里叶变换红外光谱对负载顺二氯二氨合铂（II）（顺铂，CDDP）的GdF:Er,Yb纳米粒子（GdF:Er,Yb-CDDP）进行了表征，CDDP以静电相互作用和氢键的形式负载。与单独的CDDP相比，GdF:Er,Yb-CDDP纳米粒子增加了CDDP在靶部位的浓度并提高了其抗癌效率。因此，所制备的GdF:Er,Yb-COOH纳米粒子作为有前景的抗癌诊疗剂可实现同时靶向给药和监测。
Zotero 插件