一种多功能的β-CD 修饰的 Fe3O4@ZnO:Er(3+),Yb(3+) 纳米载体，用于抗肿瘤药物输送和微波触发药物释放。

A multifunctional β-CD-modified Fe3O4@ZnO:Er(3+),Yb(3+) nanocarrier for antitumor drug delivery and microwave-triggered drug release.

机构信息

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), Shaanxi, Northwest University, Xi'an 710069, PR China; Key Laboratory of Physico-Inorganic Chemistry, School of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.

出版信息

Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:253-63. doi: 10.1016/j.msec.2014.10.022. Epub 2014 Oct 13.

DOI:10.1016/j.msec.2014.10.022

PMID:25491985

Abstract

We constructed a novel core-shell structured Fe3O4@ZnO:Er(3+),Yb(3+)@(β-CD) nanoparticles used as drug carrier to investigate the loading and controllable release properties of the chemotherapeutic drug etoposide (VP-16). The cavity of β-cyclodextrin is chemically inert, it can store etoposide molecules by means of hydrophobic interactions. The Fe3O4 core and ZnO:Er(3+),Yb(3+) shell functioned successfully for magnetic targeting and up-conversion fluorescence imaging, respectively. In addition, the ZnO:Er(3+),Yb(3+) shell acts as a good microwave absorber with excellent microwave thermal response property for microwave triggered drug release (the VP-16 release of 18% under microwave irradiation for 15 min outclass the 2% within 6h without microwave irradiation release). The release profile could be controlled by the duration and number of cycles of microwave application. This material therefore promises to be a useful noninvasive, externally controlled drug-delivery system in cancer therapy.

摘要

我们构建了一种新型的核壳结构的 Fe3O4@ZnO:Er(3+),Yb(3+)@(β-CD)纳米粒子作为药物载体，研究了化疗药物依托泊苷（VP-16）的负载和可控释放性能。β-环糊精的空腔是化学惰性的，它可以通过疏水相互作用储存依托泊苷分子。Fe3O4 核和 ZnO:Er(3+),Yb(3+)壳分别成功地用于磁靶向和上转换荧光成像。此外，ZnO:Er(3+),Yb(3+)壳具有优异的微波热响应性能，可用作良好的微波吸收剂，用于微波触发药物释放（在微波照射 15 分钟内，VP-16 的释放率为 18%，优于无微波照射 6 小时内的 2%释放率）。释放曲线可以通过微波应用的持续时间和循环次数来控制。因此，该材料有望成为一种有用的非侵入性、外部可控的癌症治疗药物输送系统。