Remote intracranial recurrence of mutant gliomas is associated with mutations and an 8q gain.

Most mutant gliomas harbor either 1p/19q co-deletions or mutation; 1p/19q co-deleted tumors have significantly better prognoses than tumors harboring mutations. To investigate the clinical factors that contribute to differences in tumor progression of mutant gliomas, we classified recurrent tumor patterns based on MRI and correlated these patterns with their genomic characterization. Accordingly, in mutant gliomas ( = 66), 1p/19 co-deleted gliomas only recurred locally, whereas mutant gliomas recurred both locally and in remote intracranial regions. In addition, diffuse tensor imaging suggested that remote intracranial recurrence in the astrocytomas, IDH-mutant with mutations may occur along major fiber bundles. Remotely recurrent tumors resulted in a higher mortality and significantly harbored an 8q gain; astrocytomas with an 8q gain resulted in significantly shorter overall survival than those without an 8q gain. OncoScan arrays and next-generation sequencing revealed specific 8q regions (i.e., between 8q22 and 8q24) show a high copy number. In conclusion, only tumors with mutations showed patterns of remote recurrence in mutant gliomas. Furthermore, an 8q gain was significantly associated with remote intracranial recurrence and can be considered a poor prognostic factor in astrocytomas, IDH-mutant.