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异柠檬酸脱氢酶（IDH）突变型星形细胞瘤的罕见轴外和颅外复发：一例报告

Unusual Extra-Axial and Extracranial Recurrence in an IDH Mutant Astrocytoma: A Case Report.

作者信息

Nair Swetha M, Sahu Arpita, Prasad Apurva, George Asha Mary, Goel Atul, Gupta Tejpal

机构信息

Department of Radiodiagnosis, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Department of Neurosurgery, Bhatia General Hospital, Mumbai, Maharashtra, India.

出版信息

Indian J Radiol Imaging. 2023 Dec 4;34(2):351-355. doi: 10.1055/s-0043-1777012. eCollection 2024 Apr.

DOI:10.1055/s-0043-1777012
PMID:38549893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10972668/
Abstract

Isocitrate dehydrogenase mutant gliomas generally have a better prognosis than their wild-type counterpart. Recurrences are generally within the radiation field in the primary tumoral bed. Remote recurrence is uncommon and is usually intraparenchymal. Transformation to a higher grade has been observed with TP53 mutants. Presentation of glioma as an extra-axial lesion is extremely uncommon. No such cases of remote intracranial extra-axial recurrence have been reported in the literature. We describe the unique imaging findings in this case and attempt to formulate possible diagnoses. Intraoperative and pathological findings confirmed this unusual recurrence pattern.

摘要

异柠檬酸脱氢酶突变型胶质瘤的预后通常比野生型胶质瘤更好。复发一般发生在原发肿瘤床的放疗区域内。远处复发并不常见，通常发生在脑实质内。TP53突变型胶质瘤已观察到向更高级别转变的情况。胶质瘤表现为轴外病变极为罕见。文献中尚未报道过这种远处颅内轴外复发的病例。我们描述了该病例独特的影像学表现，并尝试做出可能的诊断。术中及病理结果证实了这种不寻常的复发模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/543c22e045eb/10-1055-s-0043-1777012-i2392976-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/3eba68f1b72f/10-1055-s-0043-1777012-i2392976-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/ec2b3845e871/10-1055-s-0043-1777012-i2392976-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/9ee3b177ddb5/10-1055-s-0043-1777012-i2392976-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/e56da0122bb2/10-1055-s-0043-1777012-i2392976-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/36cd697a8c44/10-1055-s-0043-1777012-i2392976-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/fb79953d4f4d/10-1055-s-0043-1777012-i2392976-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/43d8c3e603d5/10-1055-s-0043-1777012-i2392976-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/543c22e045eb/10-1055-s-0043-1777012-i2392976-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/3eba68f1b72f/10-1055-s-0043-1777012-i2392976-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/ec2b3845e871/10-1055-s-0043-1777012-i2392976-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/9ee3b177ddb5/10-1055-s-0043-1777012-i2392976-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/e56da0122bb2/10-1055-s-0043-1777012-i2392976-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/36cd697a8c44/10-1055-s-0043-1777012-i2392976-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/fb79953d4f4d/10-1055-s-0043-1777012-i2392976-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/43d8c3e603d5/10-1055-s-0043-1777012-i2392976-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07d1/10972668/543c22e045eb/10-1055-s-0043-1777012-i2392976-8.jpg

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2
Subpial Hemorrhage in an Adult Male.成年男性的软膜下出血
Cureus. 2022 Aug 25;14(8):e28404. doi: 10.7759/cureus.28404. eCollection 2022 Aug.
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The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know-a minireview.世卫组织 2021 年中枢神经系统肿瘤分类：神经外科医生需要了解的实用更新——一篇迷你综述。
Acta Neurochir (Wien). 2022 Sep;164(9):2453-2464. doi: 10.1007/s00701-022-05301-y. Epub 2022 Jul 26.
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Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis.放化疗后胶质母细胞瘤与 IDH 突变型 4 级星形细胞瘤复发模式的回顾性匹配队列分析。
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221109650. doi: 10.1177/15330338221109650.
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IDH-mutant astrocytoma with EGFR amplification-Genomic profiling in four cases and review of literature.伴有EGFR扩增的异柠檬酸脱氢酶（IDH）突变型星形细胞瘤——4例病例的基因组分析及文献综述
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