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广泛异位骨化的放射治疗对症姑息治疗

Symptomatic palliation with radiotherapy in extensive heterotopic ossifications.

作者信息

Tao Mary Jiayi, Probyn Linda, Poon Michael, Kreder Hans, Wan Bo Angela, Diaz Patrick, Chow Edward

机构信息

Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

出版信息

Ann Palliat Med. 2017 Dec;6(Suppl 2):S260-S263. doi: 10.21037/apm.2017.08.10. Epub 2017 Sep 12.

Abstract

Heterotopic ossification (HTO) is the dystrophic formation of mature lamellar bone outside the confines of normal osseous tissues. It is frequently a complication which occurs following traumatic insult, both iatrogenic and non-iatrogenic, and neurological compromise. While mild degree of disease is often asymptomatic, significant pain and mobility limitations may result in reduced quality of life in advanced cases. Currently, the commonly accepted management for patients experiencing significant symptomatic HTOs is a combination therapy of surgical excision with prophylactic radiotherapy in the immediate perioperative period. In this article, we present a patient who achieved satisfactory pain relief and improvements in overall quality of life with the sole use of external beam radiation to illustrate the possibility of using radiotherapy alone for symptomatic management of HTO.

摘要

异位骨化(HTO)是指在正常骨组织范围之外形成成熟板层骨的营养不良性病变。它常常是医源性和非医源性创伤以及神经功能损害后的一种并发症。虽然轻度疾病通常无症状,但在病情严重时,明显的疼痛和活动受限可能会导致生活质量下降。目前,对于有明显症状的HTO患者,普遍接受的治疗方法是在围手术期立即进行手术切除并联合预防性放疗。在本文中,我们介绍了一名仅通过外照射放疗就实现了疼痛缓解且整体生活质量得到改善的患者,以说明单独使用放疗对HTO进行症状性治疗的可能性。

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