Bilski Mateusz, Mertowska Paulina, Mertowski Sebastian, Sawicki Marcin, Hymos Anna, Niedźwiedzka-Rystwej Paulina, Grywalska Ewelina
Department of Radiotherapy, Medical University of Lublin, Chodźki 7 St., 20-093 Lublin, Poland.
Department of Brachytherapy, St. John's Cancer Center, Jaczewskiego 7 St., 20-090 Lublin, Poland.
Cancers (Basel). 2021 Dec 30;14(1):177. doi: 10.3390/cancers14010177.
The occurrence of neuroendocrine tumors among the diagnosed neoplasms is extremely rare and is associated with difficulties in undertaking effective therapy due to the histopathological differentiation of individual subtypes and the scarce clinical data and recommendations found in the literature. The choice of treatment largely depends not only on its type, but also on the location and production of excess hormones by the tumor itself. Common therapeutic approaches include surgical removal of the tumor, the use of chemotherapy, targeted drug therapy, peptide receptor radionuclide therapy, and the use of radiation therapy. This article reviews the current knowledge on the classification and application of radiotherapy in the treatment of lung NETs. Case reports were presented in which treatment with conventional radiotherapy, radical and palliative radiochemotherapy, as well as stereotactic fractionated radiotherapy in the treatment of typical (TC) and atypical (AT) lung carcinoids and large cell neuroendocrine carcinoma (LCNC) were used. We hope that the solutions presented in the literature will allow many radiation oncologists to make the best, often personalized decisions about the therapeutic qualifications of patients.
在已确诊的肿瘤中，神经内分泌肿瘤的发生率极低，由于各亚型的组织病理学差异以及文献中稀缺的临床数据和建议，导致进行有效治疗存在困难。治疗方案的选择很大程度上不仅取决于肿瘤类型，还取决于肿瘤的位置以及肿瘤自身产生过量激素的情况。常见的治疗方法包括手术切除肿瘤、化疗、靶向药物治疗、肽受体放射性核素治疗以及放射治疗。本文综述了目前关于放射治疗在肺神经内分泌肿瘤治疗中的分类及应用的知识。文中呈现了一些病例报告，其中采用了传统放疗、根治性和姑息性放化疗以及立体定向分割放疗来治疗典型（TC）和非典型（AT）肺类癌以及大细胞神经内分泌癌（LCNC）。我们希望文献中提出的解决方案能让许多放射肿瘤学家针对患者的治疗资格做出最佳的、通常是个性化的决策。
