Kaufmann W E, Galaburda A M
Dyslexia Neuroanatomical Laboratory, Beth Israel Hospital, Boston, MA 02215.
Neurology. 1989 Feb;39(2 Pt 1):238-44. doi: 10.1212/wnl.39.2.238.
Previous studies showed that few foci of cerebro-cortical microdysgenesis (molecular layer neuronal ectopias and focal laminar dysplasia) are present in up to 26% of variably processed normal brains; they are more common in the right inferior frontal region. Brains of male developmental dyslexics processed in serial histologic sections showed 30 to 140 foci of these types of anomalies, predominantly in left perisylvian cortex. Here, we present the results of a detailed analysis of ten normal brains also processed in serial sections. The ages ranged from 3.5 to 87 years, all male. Three brains showed abnormalities similar in type to those of the dyslexic, but in far smaller numbers and in different locations: two showed a single cingulate focus--one right, one left; the third brain showed two right supratemporal foci. We conclude that the present form of developmental anomaly is rare in normal brains, and that the findings in the dyslexic brains may be significant.
以往的研究表明，在多达26%的经过不同处理的正常大脑中，存在少量脑皮质微发育异常病灶（分子层神经元异位和局灶性皮质发育异常）；它们在右侧额下回区域更为常见。对男性发育性阅读障碍患者的大脑进行连续组织学切片检查时发现，这类异常病灶有30至140个，主要分布在左侧颞周皮质。在此，我们展示了对同样进行连续切片处理的10个正常大脑的详细分析结果。这些大脑的年龄在3.5岁至87岁之间，均为男性。有3个大脑显示出与阅读障碍患者类似类型的异常，但数量少得多且位置不同：2个大脑各有一个扣带回病灶，一个在右侧，一个在左侧；第三个大脑有2个右侧颞上病灶。我们得出结论，目前这种发育异常形式在正常大脑中很少见，阅读障碍患者大脑中的这些发现可能具有重要意义。
