Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence, University of Muenster, Muenster, Germany.
Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence, University of Muenster, Muenster, Germany.
Matrix Biol. 2019 Jan;75-76:102-113. doi: 10.1016/j.matbio.2017.11.007. Epub 2017 Nov 21.
This review focuses on the complementary roles of MMP-2 and MMP-9 in leukocyte migration into the brain in neuroinflammation, studied mainly in a murine model of experimental autoimmune encephalomyelitis (EAE) that has similarity to the human disease multiple sclerosis. We discuss the cellular sources of MMP-2/MMP-9 in EAE, their sites of activity, and how cleavage of the to-date identified MMP-2/MMP-9 substrates at the blood-brain barrier facilitate leukocyte filtration of the central nervous system (CNS). Where necessary, comparisons are made to inflammatory processes in the periphery and to other MMPs relevant to neuroinflammation. While the general principles concerning MMP-2 and MMP-9 function discussed here are relevant to all inflammatory situations, the details regarding substrates and molecular mechanisms of action are likely to be specific for neuroinflammation.
这篇综述主要关注 MMP-2 和 MMP-9 在白细胞向神经炎症中的脑内迁移中的互补作用，研究主要集中在实验性自身免疫性脑脊髓炎（EAE）的小鼠模型中，该模型与人多发性硬化症疾病具有相似性。我们讨论了 MMP-2/MMP-9 在 EAE 中的细胞来源、其活性部位，以及迄今为止在血脑屏障中鉴定出的 MMP-2/MMP-9 底物的裂解如何促进白细胞对中枢神经系统（CNS）的过滤。在必要时，将与外周炎症过程和其他与神经炎症相关的 MMP 进行比较。虽然这里讨论的关于 MMP-2 和 MMP-9 功能的一般原则与所有炎症情况都有关，但关于底物和作用的分子机制的细节可能对神经炎症具有特异性。
