Department of Surgery, Duke University, Durham, NC, USA.
Duke Cancer Institute, Durham, NC, USA.
Ann Surg Oncol. 2018 Feb;25(2):512-519. doi: 10.1245/s10434-017-6254-z. Epub 2017 Nov 20.
Molecular genomic testing provides clinicians with both prognostic and (sometimes) predictive information that can help individualize treatment and decrease the risk of over- or under-treatment. We review the genomic tests that are currently available for clinical use in management of breast cancer, discuss ongoing research related to validating and expanding their utility in different patient populations, and explain why it is important for surgeons to know how to incorporate these tools into their clinical practice in order to individualize patient treatment, reduce unnecessary morbidity, and, accordingly, improve outcomes.
分子基因组检测为临床医生提供了预后和(有时)预测信息,可以帮助个体化治疗,降低过度或治疗不足的风险。我们回顾了目前可用于乳腺癌管理的基因组检测,讨论了与验证和扩大其在不同患者人群中的应用相关的正在进行的研究,并解释了为什么外科医生了解如何将这些工具纳入他们的临床实践以实现个体化患者治疗、减少不必要的发病率以及相应地改善结果非常重要。