Schneider Ruth B, Iourinets Julia, Richard Irene H
Department of Neurology, University of Rochester School of Medicine & Dentistry, 265 Crittenden Blvd, Box MIND, Rochester, NY 14642, USA.
Department of Neurology, University of Rochester School of Medicine & Dentistry, 919 Westfall Rd, Bldg C, Rochester, NY 14618, USA.
Neurodegener Dis Manag. 2017 Dec;7(6):365-376. doi: 10.2217/nmt-2017-0028. Epub 2017 Nov 21.
Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor symptoms. Psychosis is a common feature of Parkinson's disease. Parkinson's disease psychosis (PDP) encompasses minor phenomena (illusions, passage hallucinations and presence hallucinations), visual and nonvisual hallucinations and delusions. PDP is associated with reduced function and quality of life. The initial management approach should focus on identification and treatment of any contributory medical factors, reduction or discontinuation of medications with potential to induce or worsen psychosis, nonpharmacological strategies and consideration of acetylcholinesterase inhibitor treatment in the setting of dementia. Pimavanserin, quetiapine and clozapine may all be considered for use in PDP. In this review, we discuss the presentation, diagnosis and management of PDP.
帕金森病是一种以运动和非运动症状为特征的神经退行性疾病。精神病是帕金森病的常见特征。帕金森病精神病（PDP）包括轻微现象（幻觉、短暂幻觉和存在感幻觉）、视觉和非视觉幻觉以及妄想。PDP与功能减退和生活质量下降有关。初始管理方法应侧重于识别和治疗任何相关的医学因素，减少或停用可能诱发或加重精神病的药物，采取非药物策略，并在痴呆症背景下考虑使用乙酰胆碱酯酶抑制剂治疗。匹莫范色林、喹硫平和氯氮平都可考虑用于治疗PDP。在本综述中，我们讨论了PDP的表现、诊断和管理。
