Röder H U, Valchera A, Heinsohn C, Schmidt B
Radiologische Klinik, Universität Tübingen.
Strahlenther Onkol. 1989 Jan;165(1):1-10.
We report on the results of therapy of 116 patients with esophagus carcinoma. The patients have been attended to at the Medical Radiation Institute of Tübingen between 1977 and 1982. In 95 cases sole radiation was performed as operation was impossible. The other patients underwent a combined surgical-radiotherapeutical treatment. The joint doses of radiation applied ran from 50 to 70 Gy in five to seven weeks' time. In particular we considered the total survival rate according to tumor stage, the local tumor control and the period until relapse. 22% of the primarily irradiated patients achieved complete remission, 42% reached particular remission and 15% achieved minimal tumor remission (total response rate: 79%). Merely in 8% of the cases the tumor did not respond perceptibly. In the other cases irradiation had to be interrupted because of general worsening, or the patients got lost to post-therapeutical observation. The total survival rates, all stages taken into account, arose as follows: one year: 36.8%, two years: 12.6%, five years: 7.3%. After sole radiotherapy in 67% of the cases which had a radiologically verified relapse more than six months passed by before a local recurrence tumor was stated. The bad prognosis of the esophagus carcinoma, as demonstrated in literature, is entirely confirmed-the negative selection of our patients taken into account. The high rank of radiotherapy in achieving effective palliation is emphasized.
我们报告了116例食管癌患者的治疗结果。这些患者于1977年至1982年在图宾根医学放射研究所接受治疗。95例因无法进行手术而仅接受放疗。其他患者接受了手术与放疗相结合的治疗。联合放疗剂量在五至七周内为50至70戈瑞。我们特别考虑了根据肿瘤分期的总生存率、局部肿瘤控制情况以及复发前的时间。首次接受放疗的患者中,22%实现了完全缓解,42%达到部分缓解,15%实现了最小肿瘤缓解(总缓解率:79%)。仅8%的病例肿瘤无明显反应。在其他病例中,放疗因全身状况恶化而中断,或者患者失去了治疗后的观察。考虑到所有分期,总生存率如下:一年:36.8%,两年:12.6%,五年:7.3%。在仅接受放疗的病例中,67%经放射学证实复发的患者在局部复发肿瘤被发现之前超过六个月过去了。正如文献中所表明的,考虑到我们患者的负面选择,食管癌的不良预后得到了充分证实。强调了放疗在实现有效姑息治疗方面的重要地位。