Division of Fisheries Biotechnology & Molecular Biology, Department of Biotechnology, Faculty of Science and Humanities, SRM University, Kattankulathur 603 203, Chennai, Tamil Nadu, India.
Division of Fisheries Biotechnology & Molecular Biology, Department of Biotechnology, Faculty of Science and Humanities, SRM University, Kattankulathur 603 203, Chennai, Tamil Nadu, India; SRM Research Institute, SRM University, Kattankulathur 603 203, Chennai, Tamil Nadu, India.
Fish Shellfish Immunol. 2018 Jan;72:670-678. doi: 10.1016/j.fsi.2017.11.036. Epub 2017 Nov 21.
Chemokines are ubiquitous cytokine molecules involved in migration of cells during inflammation and normal physiological processes. Though the study on chemokines in mammalian species like humans have been extensively studied, characterization of chemokines in teleost fishes is still in the early stage. The present review provides an overview of chemokines and its receptors in a teleost fish, Channa striatus. C. striatus is an air breathing freshwater carnivore, which has enormous economic importance. This species is affected by an oomycete fungus, Aphanomyces invadans and a Gram negative bacteria Aeromonas hydrophila is known to cause secondary infection. These pathogens impose immune changes in the host organism, which in turn mounts several immune responses. Of these, the role of cytokines in the immune response is immense, due to their involvement in several activities of inflammation such as cell trafficking to the site of inflammation and antigen presentation. Given that importance, chemokines in fishes do have significant role in the immunological and other physiological functions of the organism, hence there is a need to understand the characteristics, activities and performace of these small molecules in details.
趋化因子是广泛存在的细胞因子分子，参与炎症和正常生理过程中的细胞迁移。尽管对人类等哺乳动物物种中的趋化因子进行了广泛研究，但硬骨鱼类中的趋化因子的特征仍然处于早期阶段。本综述提供了硬骨鱼，条纹石鮨（Channa striatus）中的趋化因子及其受体的概述。条纹石鮨是一种会呼吸空气的淡水肉食性鱼类，具有巨大的经济重要性。该物种受到卵菌真菌（Aphanomyces invadans）和革兰氏阴性细菌（Aeromonas hydrophila）的影响，已知后者会引起继发感染。这些病原体在宿主生物体内引起免疫变化，从而引发多种免疫反应。在这些反应中，细胞因子在免疫反应中的作用是巨大的，因为它们参与炎症的许多活动，例如细胞向炎症部位的迁移和抗原呈递。鉴于其重要性，鱼类中的趋化因子在生物体的免疫学和其他生理功能中确实具有重要作用，因此需要详细了解这些小分子的特征、活性和性能。
