Bretan P N, Vigneron D B, McClure R D, Hricak H, Tom R A, Moseley M, Tanagho E A, James T L
Department of Urology, University of California School of Medicine, San Francisco.
Urology. 1989 Feb;33(2):116-9. doi: 10.1016/0090-4295(89)90007-1.
To evaluate the usefulness of phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermic men after vasectomy; and group C, 11 patients presenting for infertility evaluation. Correlations between established semen analysis parameters and the 31P-MRS-derived ratio of glycerylphosphorylcholine to total phosphate (GPC/TP) were investigated. Group A controls had a mean GPC/TC ratio of 0.10 +/- 0.05, which was the same as that of group C. With the exception of significantly lowered motility and normal morphology in group C (p less than 0.001 and 0.05, respectively) semen analysis parameters in these two groups were similar. In contrast, the GPC/TP ratio in group B (0.05 +/- 0.04) was significantly different from the control (p less than 0.05), which appropriately reflected complete vasal occlusion. The results suggest that a significant portion of seminal GPC is derived from epididymal secretion and that 31P-MRS is useful for monitoring the GPC/TP levels when assessing epididymal function and male infertility.
为评估磷-31磁共振波谱（31P-MRS）在评估男性不育症中的作用，我们将其与传统精液分析进行了比较。样本取自其他方面健康的患者组，如下：A组，7名生育力正常的对照者；B组，12名输精管结扎术后无精子症男性；C组，11名前来进行不育症评估的患者。研究了既定精液分析参数与31P-MRS得出的甘油磷酰胆碱与总磷酸盐之比（GPC/TP）之间的相关性。A组对照者的平均GPC/TC比值为0.10±0.05，与C组相同。除C组的活力显著降低和形态正常外（分别p<0.001和0.05），这两组的精液分析参数相似。相比之下，B组的GPC/TP比值（0.05±0.04）与对照组有显著差异（p<0.05），这恰当地反映了完全的输精管阻塞。结果表明，精液中很大一部分GPC来自附睾分泌，并且31P-MRS在评估附睾功能和男性不育症时有助于监测GPC/TP水平。
