Mieusset R, Bujan L, Mansat A, Pontonnier F, Grandjean H, Chap H
Centre de Stérilité Masculine, Institut National de la Santé, Toulouse, France.
Int J Androl. 1988 Oct;11(5):405-13. doi: 10.1111/j.1365-2605.1988.tb01013.x.
Glycerophosphocholine (GPC) was measured in seminal plasma from 65 fertile men, 276 infertile men and 10 men before and after vasectomy, using a new enzymatic method. Extra-epididymal excretion of GPC accounted for 30% of the total seminal levels of GPC. From a diagnostic point of view, GPC determination did not appear to be a specific tool which could discriminate between secretory and excretory azoospermia. Although the seminal content of GPC was related positively to the total sperm count in both fertile and infertile men, there was an inverse relationship between the level of GPC and sperm motility when considering classes displaying the same total sperm count. This was observed in all classes from infertile men as well as in fertile men with a total sperm count lower than 200 x 10(6) sperm/ejaculate. These results suggest a possible role of GPC in the regulation of human sperm motility, which warrants further investigation.
采用一种新的酶法，对65名有生育能力的男性、276名不育男性以及10名输精管结扎术前和术后男性的精浆中的甘油磷酸胆碱（GPC）进行了测定。附睾外GPC的排泄量占精浆中GPC总量的30%。从诊断角度来看，GPC测定似乎并不是一种能够区分分泌性和排泄性无精子症的特异性工具。尽管在有生育能力和不育男性中，精浆中GPC的含量均与精子总数呈正相关，但在精子总数相同的类别中，GPC水平与精子活力呈负相关。在所有不育男性类别以及精子总数低于200×10⁶个精子/射精量的有生育能力男性中均观察到了这一现象。这些结果提示GPC在人类精子活力调节中可能发挥作用，这值得进一步研究。
