c-Met过表达在肝细胞癌中的预后价值：一项荟萃分析及综述
Prognostic value of c-Met overexpression in hepatocellular carcinoma: a meta-analysis and review.
作者信息
Kim Jung Han, Kim Hyeong Su, Kim Bum Jun, Jang Hyun Joo, Lee Jin
机构信息
Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, Republic of Korea.
Department of Internal Medicine, National Army Capital Hospital, The Armed Forces Medical Command, Sungnam 13574, Republic of Korea.
出版信息
Oncotarget. 2017 Aug 9;8(52):90351-90357. doi: 10.18632/oncotarget.20087. eCollection 2017 Oct 27.
The overexpression of c-Met protein has been detected in hepatocellular carcinoma (HCC). However, its prognostic impact remains uncertain. We performed this meta-analysis to evaluate the prognostic value of c-Met overexpression in patients who underwent curative surgical resection for HCC. A systematic computerized search of the electronic databases was carried out. From 5 studies, 1,408 patients who underwent surgical resection for HCC were included in the meta-analysis. Compared with patients with HCC having low c-Met expression, patients with c-Met-high tumor showed significantly worse relapse-free survival (hazard ratio = 1.26 [95% confidence interval, 1.02-1.56], = 0.03) and overall survival (hazard ratio = 1.16 [95% confidence interval, 1.03-1.31], = 0.01). In conclusion, our meta-analysis indicates that c-Met overexpression is a significant adverse prognostic factor for recurrence and survival in patients who underwent surgical resection for HCC.
在肝细胞癌（HCC）中已检测到c-Met蛋白的过表达。然而，其预后影响仍不确定。我们进行了这项荟萃分析，以评估c-Met过表达在接受根治性手术切除的HCC患者中的预后价值。对电子数据库进行了系统的计算机检索。从5项研究中，1408例接受HCC手术切除的患者被纳入荟萃分析。与c-Met低表达的HCC患者相比，c-Met高表达肿瘤患者的无复发生存期明显更差（风险比=1.26[95%置信区间，1.02-1.56]，P=0.03），总生存期也更差（风险比=1.16[95%置信区间，1.03-1.31]，P=0.01）。总之，我们的荟萃分析表明，c-Met过表达是接受HCC手术切除患者复发和生存的一个显著不良预后因素。
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