Kim Jung Han, Kim Hyeong Su, Kim Bum Jun, Lee Jin, Jang Hyun Joo
Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, Republic of Korea.
Department of Internal Medicine, National Army Capital Hospital, The Armed Forces Medical Command, Sungnam 13574, Republic of Korea.
Oncotarget. 2017 Aug 22;8(42):73098-73104. doi: 10.18632/oncotarget.20392. eCollection 2017 Sep 22.
The overexpression of c-Met protein has been detected in pancreatic adenocarcinoma (PAC). However, its prognostic impact remains unclear. We performed this meta-analysis to evaluate the prognostic value of c-Met overexpression in PAC. A systematic computerized search of the electronic databases such as PubMed, Embase, and Google Scholar was carried out. From 5 studies, 423 patients who underwent surgical resection for PAC were included in the meta-analysis. Compared with patients with PAC showing low c-Met expression, patients with c-Met-high tumor had significantly worse disease-free survival (hazard ratio = 1.94 [95% confidence interval, 1.46-2.56], = 0.00001) and overall survival (hazard ratio = 1.86 [95% confidence interval, 1.19-2.91], = 0.006). In conclusion, this meta-analysis demonstrates that c-Met overexpression is a significant prognostic marker for poor survival in patients who underwent surgical resection for PAC.
在胰腺腺癌（PAC）中已检测到c-Met蛋白的过表达。然而，其预后影响仍不清楚。我们进行了这项荟萃分析，以评估c-Met过表达在PAC中的预后价值。对PubMed、Embase和谷歌学术等电子数据库进行了系统的计算机检索。从5项研究中，423例行PAC手术切除的患者被纳入荟萃分析。与c-Met低表达的PAC患者相比，c-Met高表达肿瘤患者的无病生存期（风险比=1.94[95%置信区间，1.46-2.56]，P=0.00001）和总生存期（风险比=1.86[95%置信区间，1.19-2.91]，P=0.006）显著更差。总之，这项荟萃分析表明，c-Met过表达是行PAC手术切除患者生存不良的一个重要预后标志物。
