Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Eur Radiol. 2018 Apr;28(4):1756-1760. doi: 10.1007/s00330-017-5147-7. Epub 2017 Nov 21.
Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects.
Data used in the preparation of this article were obtained from Parkinson's Progression Markers Initiative database ( www.ppmi-info.org/data ). The study population consisted of healthy controls with screening I-FP-CIT single photon emission tomography (SPECT). University of Pennsylvania Smell Identification Test (UPSIT) was assessed to evaluate the olfactory function.
Totally, 181 healthy subjects (117 male, 64 female) with I-FP-CIT SPECT data were included in this study. Specific binding ratios (SBRs) of the caudate nucleus (rho = -0.4217, p < 0.0001), putamen (rho = -0.2292, p = 0.0019), and striatum (rho=-0.3425, p < 0.0001) showed a reduction with ageing. SBRs of the caudate nucleus, putamen, and striatum were positively correlated with UPSIT (rho = 0.3716, p < 0.0001; rho = 0.3655, p < 0.0001; rho = 0.3880, p < 0.0001). After controlling for age by partial correlation, SBRs of the caudate nucleus, putamen, and striatum showed an influence on UPSIT (rho = 0.3288, p < 0.0001; rho = 0.3374, p < 0.0001; rho = 0.3511, p < 0.0001).
Olfactory function is associated with the availability of striatal DAT independent of age in healthy subjects.
• Olfactory dysfunction in Parkinson's disease is prodromal to other symptoms. • The availability of dopamine transporter showed a reduction with ageing. • Olfactory function is associated with the availability of dopamine transporter.
帕金森病患者的嗅觉功能障碍通常是其他症状的前驱症状。在这项研究中，我们旨在探讨嗅觉功能与健康受试者纹状体多巴胺转运体（DAT）可用性的关系。
本文数据来源于帕金森进展标志物倡议数据库（www.ppmi-info.org/data）。研究人群包括有筛查 I-FP-CIT 单光子发射断层扫描（SPECT）的健康对照者。采用宾夕法尼亚大学嗅觉识别测试（UPSIT）评估嗅觉功能。
本研究共纳入 181 名有 I-FP-CIT SPECT 数据的健康受试者（男性 117 名，女性 64 名）。尾状核（rho=-0.4217，p<0.0001）、壳核（rho=-0.2292，p=0.0019）和纹状体（rho=-0.3425，p<0.0001）的特异性结合率（SBR）随年龄增长而降低。尾状核、壳核和纹状体的 SBR 与 UPSIT 呈正相关（rho=0.3716，p<0.0001；rho=0.3655，p<0.0001；rho=0.3880，p<0.0001）。通过偏相关控制年龄因素后，尾状核、壳核和纹状体的 SBR 对 UPSIT 仍有影响（rho=0.3288，p<0.0001；rho=0.3374，p<0.0001；rho=0.3511，p<0.0001）。
在健康受试者中，嗅觉功能与纹状体 DAT 的可用性有关，而与年龄无关。
帕金森病患者的嗅觉功能障碍是其他症状的前驱症状。
多巴胺转运体的可用性随年龄增长而降低。
嗅觉功能与多巴胺转运体的可用性有关。
