Marcial José, Altieri Pablo I, Banchs Héctor L
Bol Asoc Med P R. 2016;108(2):21-9.
We report clinical and molecular mechanisms relating the process of inflammation involved in the progression of obesity and the metabolic syndrome, emphasizing the cardiovascular problems developed in Hispanic populations. Namely, the incidence, component characteristics and complications of obesity and metabolic syndrome in island Puerto Ricans are described and evidence is presented supporting the fact that the metabolic syndrome may be milder in Puerto Rico than in the mainland United States because it is characterized by less aggressive coronary artery disease and a relatively normal lipid profile. Moreover, data supports the fact that increased serum cholesterol levels produce less myocardial infarctions in Puerto Rico than in mainland Hispanics and Caucasians. In addition, the incidence of ventricular tachycardia, a complication caused by remodeling and ischemia of the heart, may be lower in Puerto Rico than in the United States, although the prevalence of the metabolic syndrome is higher in the island. On the other hand, there is evidence of a rising epidemic of obesity and vascular inflammation in Puerto Rico that suggests that cardiovascular morbidity and mortality in the island will continue to increase in the future decades.
我们报告了与肥胖和代谢综合征进展过程中涉及的炎症过程相关的临床和分子机制，重点关注西班牙裔人群中出现的心血管问题。具体而言，描述了波多黎各岛肥胖和代谢综合征的发病率、组成特征及并发症，并提供证据支持代谢综合征在波多黎各可能比美国大陆更为温和这一事实，因为其特征是冠状动脉疾病不那么严重且血脂谱相对正常。此外，数据支持以下事实：与美国大陆的西班牙裔和白种人相比，波多黎各血清胆固醇水平升高导致的心肌梗死更少。另外，尽管该岛代谢综合征的患病率较高，但由心脏重塑和缺血引起的并发症室性心动过速的发病率在波多黎各可能低于美国。另一方面，有证据表明波多黎各肥胖和血管炎症呈流行趋势上升，这表明该岛未来几十年心血管疾病的发病率和死亡率将持续增加。
