Kawabe Y, Sugiyama S, Kuroiwa M, Takano K, Goto H, Nakazawa S, Ozawa T
Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan.
Am J Gastroenterol. 1989 Feb;84(2):138-42.
We investigated the different effects of administration of high and low concentrations of ethanol (from 3% to 50%) on gastric mucosa in rats in relation to the changes in prostaglandin (PG) levels. Gastric lesions were induced by 50% ethanol, and all kinds of PGs were significantly decreased 1 h after administration, concomitantly. Thirty percent ethanol did not induce gastric lesions and had no effects on PG levels. Five percent ethanol significantly increased 6-keto-PGF1 alpha, PGF2 alpha, and PGE2 levels. Ten percent ethanol increased significantly PGD2 level. Premedication with sucralfate protected significantly gastric mucosa against 50% ethanol, and maintained PG levels, concomitantly. We also investigated the recovery time course of gastric lesions by 50% ethanol. Gastric lesions did not recover significantly after 24 h, recovered considerably after 48 h, and fully after 96 h. Levels of 6-keto-PGF1 alpha, PGF2 alpha, and PGE2 were fully recovered 24 h after exposure to 50% ethanol; however, a significant decrease in PGD2 level still was observed. PGD2 was recovered significantly after 48 h. These results indicate that different concentrations of ethanol induce different effects on gastric mucosal PGs, and that not only PGE2, but also other PGs, especially PGD2, might be linked with the genesis and recovery of gastric lesions by 50% ethanol.
我们研究了高浓度和低浓度乙醇（3%至50%）给药对大鼠胃黏膜的不同影响及其与前列腺素（PG）水平变化的关系。50%乙醇可诱发胃损伤，给药1小时后所有种类的PG均显著降低。30%乙醇未诱发胃损伤，且对PG水平无影响。5%乙醇可显著提高6-酮-前列腺素F1α、前列腺素F2α和前列腺素E2水平。10%乙醇可显著提高前列腺素D2水平。预先给予硫糖铝可显著保护胃黏膜免受50%乙醇损伤，并同时维持PG水平。我们还研究了50%乙醇所致胃损伤的恢复时间进程。胃损伤在24小时后未显著恢复，48小时后有明显恢复，96小时后完全恢复。暴露于50%乙醇24小时后，6-酮-前列腺素F1α、前列腺素F2α和前列腺素E2水平完全恢复；然而，仍观察到前列腺素D2水平显著降低。48小时后前列腺素D2显著恢复。这些结果表明，不同浓度的乙醇对胃黏膜PG有不同影响，不仅前列腺素E2，而且其他PG，尤其是前列腺素D2，可能与50%乙醇所致胃损伤的发生和恢复有关。
