Kinoshita T, Nimura Y, Shionoya S, Goto H, Ozawa T
Biochem Int. 1987 Feb;14(2):303-9.
We have developed a method for measuring prostaglandins (PGs) in rat gastric mucosa by high-performance liquid chromatography (HPLC). The levels of PGD2 and 6-keto-PGF1 alpha, a degradation product of PGI2, were five times higher than those of PGE2 and PGF2 alpha. Oral administration of indomethacin (6 mg/kg body weight) completely abolished the synthesis of all detectable PGs uniformly. These results suggest that endogenous PGs, especially PGD2 and I2, play some roles in the function of the gastric mucosa.
我们已经开发出一种通过高效液相色谱法（HPLC）测量大鼠胃黏膜中前列腺素（PGs）的方法。PGD2和6-酮-PGF1α（PGI2的一种降解产物）的水平比PGE2和PGF2α高五倍。口服吲哚美辛（6毫克/千克体重）能完全均匀地消除所有可检测到的PGs的合成。这些结果表明，内源性PGs，尤其是PGD2和I2，在胃黏膜的功能中发挥着一些作用。
