Lacerda Isabel B, Santos Raquel L, Neto José Pedro Simões, Dourado Marcia C N
Center for Alzheimer's Disease, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro.
Sociology and Political Science Department, Universidade Federal de Santa, Catarina, Florianópolis, SC, Brazil.
Alzheimer Dis Assoc Disord. 2017 Oct-Dec;31(4):335-342. doi: 10.1097/WAD.0000000000000210.
Awareness of deficits is a multidimensional phenomenon described as the ability to acknowledge difficulties and impairments. We investigated whether unawareness affects distinct domains to different degrees and identified the factors related to the awareness impairment in Alzheimer Disease (AD). Using a cross-sectional design, we assessed 89 people with AD (PwAD) and their caregivers. Awareness was evaluated by scoring discrepant responses between PwAD and their caregivers across domains including cognitive functioning and health condition, functional activity impairments, emotional state, social functioning, and interpersonal relationships. The awareness of functional activity impairments domain showed a greater discrepancy compared with the other domains. Multiple regression analysis revealed that lack of awareness of cognitive functioning and health condition was related to PwAD unawareness of functional activity impairments, age, and caregiver burden. The emotional state domain was related to PwAD unawareness of functional activity impairments and depressive symptoms. There was also a relationship between the social functioning and relationships domain and caregiver burden. The functional activity impairments domain was related to deficits in the following domains: cognitive functioning and health condition, emotional state, social and emotional functioning, and PwAD self-reported quality of life. Although we observed that 1 domain can influence another, our results suggest that the factors related to each of the different objects of awareness are varied.
对缺陷的认知是一种多维度现象，被描述为承认困难和损伤的能力。我们调查了无意识是否会对不同领域产生不同程度的影响，并确定了与阿尔茨海默病（AD）认知障碍相关的因素。采用横断面设计，我们评估了89名AD患者（PwAD）及其照顾者。通过对PwAD及其照顾者在包括认知功能和健康状况、功能活动障碍、情绪状态、社会功能和人际关系等领域的差异反应进行评分来评估认知情况。与其他领域相比，功能活动障碍领域的认知差异更大。多元回归分析显示，对认知功能和健康状况缺乏认知与PwAD对功能活动障碍的无意识、年龄和照顾者负担有关。情绪状态领域与PwAD对功能活动障碍的无意识和抑郁症状有关。社会功能和人际关系领域与照顾者负担之间也存在关联。功能活动障碍领域与以下领域的缺陷有关：认知功能和健康状况、情绪状态、社会和情感功能以及PwAD自我报告的生活质量。尽管我们观察到一个领域可以影响另一个领域，但我们的结果表明，与每个不同认知对象相关的因素各不相同。
