Arantes Luana Bernardes, Reis Carmélia Santiago, Novaes Alice Garbi, Carvalho Marta Rodrigues de, Göttems Leila Bernarda Donato, Novaes Maria Rita Carvalho Garbi
Burn sector of Hospital Regional da Asa Norte - Secretaria de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil.
Department of Dermatology of Hospital Regional da Asa Norte - Secretaria de Estado de Saúde do Distrito Federal (SES-DF) - Brasília (DF), Brazil.
An Bras Dermatol. 2017 Sep-Oct;92(5):661-667. doi: 10.1590/abd1806-4841.20176610.
Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.
To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil.
Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients.
There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital.
There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.
药物不良反应是在用于特定病症的正常剂量下发生的对药物的有害且非自愿的反应。其中包括史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症，这两种病症均罕见且有潜在致命风险。
分析巴西联邦区公立医院中被诊断为史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的患者的流行病学和临床特征。
回顾性、横断面描述性研究，收集1999年至2014年在联邦区公共医疗系统住院患者的数据。结果：1999年至2014年，联邦区报告了86例住院诊断为史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的患者。大多数患者为女性；受影响最严重的年龄组为0至10岁。60岁以上（老年）患者占病例的6.98%。转诊医院收治的大多数患者出院。然而，老年患者的死亡人数超过出院人数。
无论是医院信息系统还是转诊医院的病历中，患者住院登记都存在缺陷。
需要更多地收集并更好地传播关于药物不良反应发生率的信息。
