Alnofaiey Yasser H, AlTalhi Wjood A, Altalhi Wahaj A, Alsulaimani Abeer I, Alkhaldi Layla M
Department of Internal Medicine, Collage of Medicine, Taif University, Taif, SAU.
Family Medicine, Ministry of Health, Taif, SAU.
Cureus. 2022 Dec 7;14(12):e32303. doi: 10.7759/cureus.32303. eCollection 2022 Dec.
Medicines often cause serious immune-mediated mucocutaneous reactions including Steven-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). In the acute phase of SJS and TEN, a febrile illness is followed by cutaneous erythema with blister formation, skin and mucous membrane necrosis, and separation of the skin and mucous membranes. The patient swiftly becomes in danger of dying, necessitating immediate medical attention. In this case report, we described a case of Steven-Johnson Syndrome in a 102-year-old female who was receiving palliative care and had stage 5 chronic renal disease. Although the agent that caused SJS in this patient is unknown, the patient was managed with topical medication, bandages for the lesions, and oral antihistamines. Skin biopsy, abdomen ultrasound, and sezary cell test were advised for the patient. Such presentations at that age have not, to our knowledge, been documented before.
药物常常会引发严重的免疫介导性皮肤黏膜反应,包括史蒂文斯-约翰逊综合征(SJS)和中毒性表皮坏死松解症(TEN)。在SJS和TEN的急性期,先是出现发热性疾病,随后皮肤出现红斑并形成水疱,皮肤和黏膜坏死,皮肤与黏膜分离。患者很快就会面临死亡危险,需要立即就医。在本病例报告中,我们描述了一名102岁接受姑息治疗且患有5期慢性肾病的女性史蒂文斯-约翰逊综合征病例。虽然导致该患者发生SJS的药物尚不清楚,但对患者采用了局部用药、对皮损进行包扎以及口服抗组胺药的治疗方法。建议对该患者进行皮肤活检、腹部超声检查和塞扎里细胞检测。据我们所知,此前尚未有过该年龄段出现此类症状的记录。