Faridi Farnaz, Khosrowabadi Reza
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
Basic Clin Neurosci. 2017 Sep-Oct;8(5):349-359. doi: 10.18869/nirp.bcn.8.5.349.
Asperger syndrome (AS) is a subtype of Autism Spectrum Disorder (ASD) characterized by major problems in social and nonverbal communication, together with limited and repetitive forms of behavior and interests. The linguistic and cognitive development in AS is preserved which help us to differentiate it from other subtypes of ASD. However, significant effects of AS on cognitive abilities and brain functions still need to be researched. Although a clear cut pathology for Asperger has not been identified yet, recent studies have largely focused on brain imaging techniques to investigate AS. In this regard, we carried out a systematic review on behavioral, cognitive, and neural markers (specifically using MRI and fMRI) studies on AS. In this paper, behavior, motor skills and language capabilities of individuals with Asperger are compared to those in healthy controls. In addition, common findings across MRI and fMRI based studies associated with behavior and cognitive disabilities are highlighted.
阿斯伯格综合征（AS）是自闭症谱系障碍（ASD）的一种亚型，其特征是在社交和非语言交流方面存在重大问题，同时伴有有限的重复性行为和兴趣模式。阿斯伯格综合征患者的语言和认知发展得以保留，这有助于我们将其与自闭症谱系障碍的其他亚型区分开来。然而，阿斯伯格综合征对认知能力和脑功能的显著影响仍有待研究。尽管尚未确定阿斯伯格综合征的确切病理，但最近的研究主要集中在脑成像技术上，以研究阿斯伯格综合征。在这方面，我们对关于阿斯伯格综合征的行为、认知和神经标志物（特别是使用MRI和fMRI）的研究进行了系统综述。在本文中，将阿斯伯格综合征患者的行为、运动技能和语言能力与健康对照组进行了比较。此外，还强调了基于MRI和fMRI的研究中与行为和认知障碍相关的常见发现。
