Severo Julia So, Santana Aline Elisa, Aoki Valeria, Michalany Nilceo S, Mantovani Matheus Matioli, Larsson Carlos Eduardo, Larsson Carlos Eduardo
Department of Clinical Science, School of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando M. Paiva, 87, São Paulo, SP, 05508-270, Brazil.
Department of Dermatology, School of Medicine, University of São Paulo, Av. Dr. Eneas C. Aguiar, 255, São Paulo, SP, 05403-000, Brazil.
Vet Dermatol. 2018 Apr;29(2):128-e51. doi: 10.1111/vde.12510. Epub 2017 Nov 22.
C-reactive protein (CRP) is a major acute phase protein in dogs and may be an inflammatory marker of autoimmune diseases.
HYPOTHESIS/OBJECTIVES: To measure pre- and post-treatment CRP levels in dogs with superficial pyoderma (SP) and pemphigus foliaceus (PF) compared to normal dogs; to evaluate possible correlation between CRP values, indirect immunofluorescence (IIF), and pemphigus foliaceus extent and severity index (PEFESI) scores.
Fifty nine dogs divided into three groups: Group I (control, n = 31), Group II (SP, n = 14) and Group III (PF, n = 14).
CRP levels were measured in Group I dogs. Skin biopsies of Groups II and III dogs were obtained for histopathological examination. In Group II dogs, CRP levels were measured at days 0, 15, 30 and 60. In Group III dogs were evaluated by PEFESI, IIF and CRP levels at days 0, 15, 30, 60 and 90.
Group III showed a higher median CRP (37.4 mg/mL) compared to the other groups (Group I, CRP 2.9 mg/mL, P < 0.0001; Group II CRP 3.8 mg/mL, P = 0.008). There was no significant difference in CRP levels between groups I and II. IIF titres and CRP levels decreased in most cases of PF with clinical improvement. Dogs with CRP >10.6 μg/mL were 5.5 times more likely to have PF than SP. There was a strong positive correlation between CRP values and PEFESI and a weak positive correlation between CRP values and IIF titres.
CRP levels are increased in dogs with PF and exceed levels found in most dogs with SP.
C反应蛋白（CRP）是犬类主要的急性期蛋白，可能是自身免疫性疾病的炎症标志物。
假设/目的：测量浅表脓皮病（SP）和落叶型天疱疮（PF）犬治疗前后的CRP水平，并与正常犬进行比较；评估CRP值、间接免疫荧光（IIF）以及落叶型天疱疮范围和严重程度指数（PEFESI）评分之间的可能相关性。
59只犬分为三组：第一组（对照组，n = 31），第二组（SP，n = 14）和第三组（PF，n = 14）。
测量第一组犬的CRP水平。获取第二组和第三组犬的皮肤活检样本进行组织病理学检查。在第二组犬中，于第0、15、30和60天测量CRP水平。在第三组犬中，于第0、15、30、60和90天通过PEFESI、IIF和CRP水平进行评估。
与其他组相比，第三组的CRP中位数更高（37.4 mg/mL）（第一组，CRP 2.9 mg/mL，P < 0.0001；第二组CRP 3.8 mg/mL，P = 0.008）。第一组和第二组之间的CRP水平无显著差异。在大多数临床症状改善的PF病例中，IIF滴度和CRP水平下降。CRP>10.6μg/mL的犬患PF的可能性是患SP的5.5倍。CRP值与PEFESI之间存在强正相关，CRP值与IIF滴度之间存在弱正相关。
PF犬的CRP水平升高，且超过大多数SP犬的水平。
