Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0563, Medical Sciences Bldg. (MSB), Cincinnati, OH.
Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Semin Arthritis Rheum. 2018 Apr;47(5):710-717. doi: 10.1016/j.semarthrit.2017.10.001. Epub 2017 Oct 5.
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect almost any organ in the human body. Despite significant advancements in our understanding of SLE over the recent years, its exact mode of onset and disease progression remains elusive. Low concordance rates among monozygotic twins with SLE (as low as 24%), clustering of disease prevalence around polluted regions and an urban-rural difference in prevalence all highlight the importance of environmental influences in SLE. Experimental data strongly suggests a complex interaction between the exposome (or environmental influences) and genome (genetic material) to produce epigenetic changes (epigenome) that can alter the expression of genetic material and lead to development of disease in the susceptible individual. In this review, we focus on the available literature to explore the role of environmental factors in SLE disease onset and progression and to better understand the role of exposome-epigenome-genome interactions in this dreaded disease.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，几乎可以影响人体的任何器官。尽管近年来我们对 SLE 的认识有了显著的提高，但它的确切发病模式和疾病进展仍然难以捉摸。SLE 同卵双胞胎的一致性率低（低至 24%）、疾病流行在污染地区周围聚集以及城乡患病率差异，都凸显了环境因素在 SLE 中的重要性。实验数据强烈表明，外显子组（或环境影响）与基因组（遗传物质）之间存在复杂的相互作用，产生表观遗传变化（表观基因组），从而改变遗传物质的表达，并导致易感个体发生疾病。在这篇综述中，我们重点关注现有文献，探讨环境因素在 SLE 发病和进展中的作用，并更好地理解外显子组-表观基因组-基因组相互作用在这种可怕疾病中的作用。
