Jin Hui, Zhao Ming, Lu Qianjin
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China.
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China.
Trends Mol Med. 2021 Sep;27(9):839-843. doi: 10.1016/j.molmed.2021.06.006. Epub 2021 Jul 3.
As an extremely heterogeneous disease, lupus erythematosus (LE) occurs when a genetically susceptible individual encounters specific environmental triggers. Epigenetics bridges genetics and environment and helps explain their interactions. Comprehensively understanding the hidden mysteries behind the genome, epigenome, and exposome of lupus could contribute to precision prevention and treatment of lupus.
红斑狼疮（LE）是一种极其异质性的疾病，当具有遗传易感性的个体遇到特定的环境触发因素时就会发病。表观遗传学架起了遗传学与环境之间的桥梁，并有助于解释它们之间的相互作用。全面了解狼疮的基因组、表观基因组和暴露组背后隐藏的奥秘，可能有助于狼疮的精准预防和治疗。
