Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha 410011.
Department of Rheumatology and Immunology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jul 28;47(7):967-972. doi: 10.11817/j.issn.1672-7347.2022.210335.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect almost every organ in the human body. The etiology and pathogenesis are unclear. Recent studies have shown that pathogenesis and development of SLE result from the interaction between various internal and external factors. Current studies suggest that air pollution may increase the risk of SLE through multiple mechanisms such as inducing immune disorders, causing epigenetic changes, and inducing oxidative stress. Air pollution has a certain relationship with pulmonary interstitial lesions, lupus nephritis, decreased reproductive function and other system damages in SLE patients, and it is related to the occurrence and clinical outcomes of SLE. Air pollution has a potential role in the occurrence and development of SLE, providing a brand-new view on the early prevention and control of SLE.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，几乎可以影响人体的每一个器官。其病因和发病机制尚不清楚。最近的研究表明，SLE 的发病机制和发展是由各种内部和外部因素相互作用的结果。目前的研究表明，空气污染可能通过诱导免疫紊乱、引起表观遗传改变和诱导氧化应激等多种机制增加 SLE 的患病风险。空气污染与 SLE 患者的肺间质病变、狼疮肾炎、生殖功能下降等其他系统损害有关，与 SLE 的发生和临床结局有关。空气污染在 SLE 的发生和发展中具有潜在作用，为 SLE 的早期预防和控制提供了全新的视角。
