McDermott M L, Edelhauser H F
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226.
Arch Ophthalmol. 1989 Feb;107(2):261-3. doi: 10.1001/archopht.1989.01070010267034.
When viscoelastic agents that contain hyaluronate sodium are used during anterior segment surgical procedures, it is common for some of the material to remain intraocularly after the surgery is completed. A variety of drugs, used intracamerally or topically following surgery, are also present. These drugs may be bound to the polyanionic hyaluronate molecule. This occurrence may cause drug alterations in therapeutic effectiveness, pharmacokinetics, and toxicity. To investigate the possibility for drug-viscoelastic agent adsorption, in vitro drug-binding studies were performed on three commercial viscoelastic agents; undiluted aliquots of Amvisc, Healon, or Viscoat were mixed with radiolabeled D-threo-chloramphenicol, dexamethasone, L-epinephrine, or pilocarpine hydrochloride, placed in dialysis membranes, and dialyzed for 24 hours against an isotonic phosphate buffer. The calculated drug binding by a viscoelastic agent ranged from 0% to 1.5%. These extremely low values for in vitro drug uptake by viscoelastic agents made it unlikely that any significant drug-viscoelastic agent interaction would occur in the postoperative eye.
在前节手术过程中使用含透明质酸钠的粘弹剂时，手术完成后眼内残留部分材料是很常见的。术后还会在眼内前房或局部使用多种药物。这些药物可能会与聚阴离子透明质酸分子结合。这种情况可能会导致药物在治疗效果、药代动力学和毒性方面发生改变。为了研究药物与粘弹剂吸附的可能性，对三种市售粘弹剂进行了体外药物结合研究；将未稀释的Amvisc、Healon或Viscoat等分试样与放射性标记的D-苏式氯霉素、地塞米松、L-肾上腺素或盐酸毛果芸香碱混合，置于透析膜中，并在等渗磷酸盐缓冲液中透析24小时。计算得出粘弹剂对药物的结合率在0%至1.5%之间。粘弹剂对药物的体外摄取量极低，因此术后眼内不太可能发生任何显著的药物与粘弹剂相互作用。
