尿筛检测早期肾脏病。
Urinary Screening for Early Detection of Kidney Diseases.
机构信息
Department of Pathology, Lab Medicine, Transfusion Services & Immunohematology, G.R. Doshi and K.M Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, 380016, India.
Department of Regenerative Medicine and Cell Therapy, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India.
出版信息
Indian J Pediatr. 2018 Aug;85(8):607-612. doi: 10.1007/s12098-017-2494-y. Epub 2017 Nov 23.
OBJECTIVE
Urinary screening is a simple inexpensive tool to evaluate kidney functions. The authors carried out urinary screening of school children for early detection of kidney diseases.
METHODS
Children in the age group 5-15 y were screened for urinalysis. They were divided in 2 groups; group-1 included 5-10 y and group-2 included >10-15 y old children.
RESULTS
Urine samples of 3340(78%) out of 4283 enrolled children were tested. Abnormal samples were found in 5.75%; with proteinuria in 4.59%, pyuria in 3.29% and hematuria in 4.31%. Males constituted 47.71% in group-1 and 54.64% in group-2. Low body mass index was found in 94.1% group-1 and 78.99% group-2 children. Mild proteinuria was found in 1.2% group-1 and 2.56% group-2 children. Severe proteinuria was more in group-2 (0.77% vs. 0.06%) with female preponderance. Glucosuria was found in 1 boy of group-2. Urobilinogen was more in group-2 (0.65% vs. 0.24%) with male preponderance. Nitrituria was found in 9 girls. Pyuria (2.02% vs. 1.27%) and hematuria were more in group-2 (3.04% vs. 1.87%) with female preponderance. Combined proteinuria and hematuria (0.42% vs. 0.24%) as well bacteruria and fungaluria were more in group-2 (4.11% vs. 1.39%). Six of 192 children with abnormal urinary findings were treated; 1 for urinary calculus and 5 for urinary tract infection.
CONCLUSIONS
Abnormal urinary findings were more common in children >10 y of age. Thus urinary screening program of children can become useful for early detection of kidney diseases and contribute towards building up of a healthy nation.
目的
尿液筛查是一种简单且廉价的评估肾脏功能的工具。作者对学龄儿童进行了尿液筛查，以早期发现肾脏疾病。
方法
对 5-15 岁的儿童进行尿液分析筛查。他们被分为两组：第 1 组为 5-10 岁，第 2 组为>10-15 岁。
结果
对 4283 名入组儿童中的 3340 名（78%）进行了尿液样本检测。异常样本占 5.75%，其中蛋白尿占 4.59%、脓尿占 3.29%、血尿占 4.31%。第 1 组男性占 47.71%，第 2 组男性占 54.64%。第 1 组儿童中低体重指数占 94.1%，第 2 组儿童中低体重指数占 78.99%。第 1 组儿童中轻度蛋白尿占 1.2%，第 2 组儿童中轻度蛋白尿占 2.56%。第 2 组儿童中重度蛋白尿更多（0.77%比 0.06%，女性占优势）。第 2 组 1 名男孩出现糖尿。第 2 组尿胆原更多（0.65%比 0.24%，男性占优势）。第 2 组儿童中 9 名女孩出现亚硝酸盐尿。脓尿（2.02%比 1.27%）和血尿（3.04%比 1.87%）在第 2 组更为常见（女性占优势）。第 2 组联合蛋白尿和血尿（0.42%比 0.24%）以及菌尿和真菌尿（4.11%比 1.39%）更为常见。192 名尿液异常发现的儿童中，有 6 名接受了治疗；1 名患有尿路结石，5 名患有尿路感染。
结论
10 岁以上儿童尿液异常更为常见。因此，儿童尿液筛查计划可用于早期发现肾脏疾病，有助于建设健康国家。
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