Singapore Centre for 3D Printing (SC3DP), Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, 639798, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Biosens Bioelectron. 2018 Apr 15;102:365-371. doi: 10.1016/j.bios.2017.11.039. Epub 2017 Nov 16.
Bioelectronics platforms are gaining widespread attention as they provide a template to study the interactions between biological species and electronics. Decoding the effect of the electrical signals on the cells and tissues holds the promise for treating the malignant tissue growth, regenerating organs and engineering new-age medical devices. This work is a step forward in this direction, where bio- and electronic materials co-exist on one platform without any need for post processing. We fabricate a freestanding and flexible hydrogel based platform using 3D bioprinting. The fabrication process is simple, easy and provides a flexible route to print materials with preferred shapes, size and spatial orientation. Through the design of interdigitated electrodes and heating coil, the platform can be tailored to print various circuits for different functionalities. The biocompatibility of the printed platform is tested using C2C12 murine myoblasts cell line. Furthermore, normal human dermal fibroblasts (primary cells) are also seeded on the platform to ascertain the compatibility.
生物电子平台受到广泛关注，因为它们为研究生物物种与电子之间的相互作用提供了模板。解码电信号对细胞和组织的影响有望治疗恶性组织生长、器官再生和工程新型医疗设备。这项工作是朝着这一方向迈出的一步，生物和电子材料在无需后处理的情况下共存于一个平台上。我们使用 3D 生物打印制造了一个独立的、灵活的水凝胶基平台。制造过程简单、易用，并提供了一种灵活的途径，可以用所需的形状、尺寸和空间方向打印材料。通过设计叉指电极和加热线圈，可以根据不同的功能对平台进行定制以打印各种电路。使用 C2C12 鼠骨骼肌母细胞系测试了打印平台的生物相容性。此外，还在平台上接种了正常人皮肤成纤维细胞（原代细胞），以确定其兼容性。
