Department of Psychology, Queens College, The City University of New York, Queens, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, China; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, Anhui Province, China; Department of Neurology, The Second Hospital of Anhui Province, Hefei, Anhui Province, China.
J Psychiatr Res. 2018 Feb;97:22-29. doi: 10.1016/j.jpsychires.2017.11.002. Epub 2017 Nov 5.
Although a deficit in executive control of attention is one of the hallmarks in schizophrenia that has significant impact on everyday functioning due to its relationship with thought processing, whether this deficit occurs across modalities, i.e., is supramodal, remains unclear. To investigate the supramodal mechanism in SZ, we examined cross-modal correlations between visual and auditory executive control of attention in a group of patients with schizophrenia (SZ, n = 55) compared to neurotypical controls (NC, n = 55). While the executive control effects were significantly correlated between the two modalities in the NC group, these effects were not correlated in the SZ group, with a significant group difference in the correlation. Further, the inconsistency and magnitude of the cross-modal executive control effects were significantly larger in the SZ group compared to the NC group. Together, these results suggest that there is a disruption of a common supramodal executive control mechanism in patients with schizophrenia, which may be related to the thought processing disorder characterizing the disorder.
尽管注意的执行控制缺陷是精神分裂症的特征之一，由于它与思维处理有关，因此对日常功能有重大影响，但这种缺陷是否跨越模态，即是否超模式，尚不清楚。为了研究 SZ 的超模态机制，我们在一组精神分裂症患者（SZ，n=55）和神经典型对照组（NC，n=55）中检查了视觉和听觉注意力执行控制之间的跨模态相关性。虽然在 NC 组中，两种模式之间的执行控制效果显著相关，但在 SZ 组中，这些效果没有相关性，并且在相关性方面存在显著的组间差异。此外，与 NC 组相比，SZ 组的跨模态执行控制效果的不一致性和幅度明显更大。总的来说，这些结果表明，精神分裂症患者存在一种共同的超模式执行控制机制的破坏，这可能与该疾病特征的思维处理障碍有关。
