在一个基于爱尔兰人群的样本中，叶黄素和玉米黄质的血浆浓度与年龄相关性黄斑变性的自我报告患病率和实际患病率之间的关系。

The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample.

作者信息

Moran Rachel, Beatty Stephen, Stack Jim, O'Halloran Aisling M, Feeney Joanne, Akuffo Kwadwo O, Peto Tunde, Kenny Rose Anne, Nolan John M

机构信息

a Macular Pigment Research Group, Nutrition Research Centre Ireland, School of Health Science, Waterford Institute of Technology , Waterford , Ireland.

b The Irish Longitudinal Study on Ageing, Department of Medical Gerontology , Trinity College , Dublin , Ireland.

出版信息

Curr Eye Res. 2018 Mar;43(3):383-390. doi: 10.1080/02713683.2017.1403633. Epub 2017 Nov 27.

DOI:10.1080/02713683.2017.1403633

PMID:29172786

Abstract

PURPOSE

To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD).

MATERIAL AND METHODS

Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware; Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence of AMD.

RESULTS

Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs, 288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and age, the relationship between grading-confirmed AMD and plasma L was positive and significant (p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 µmol) and Group 4 (mean = 0.2040 ± 0.121 µmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 µmol/L) and Group 3 (mean = 0.3176 ± 0.0.235 µmol/L). Supplement use was reported by 41.7% and 17.1% of participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4, respectively.

CONCLUSION

A belief that one suffers from AMD, whether justified or not, is associated with supplement use and with higher plasma concentrations of L.

摘要

目的

研究血浆叶黄素（L）和玉米黄质（Z）浓度与经分级确认及自我报告的年龄相关性黄斑变性（AMD）患病率之间的关系。

材料与方法

数据来自爱尔兰共和国一项具有全国代表性的针对50岁及以上社区居住成年人的前瞻性队列研究。参与者接受了计算机辅助个人访谈和基于中心的健康评估。采用高效液相色谱法测定血浆L和总Z（Z和内消旋玉米黄质[MZ]）的浓度，并使用AMD国际分类和分级系统的一个版本对视网膜照片进行分级。记录含有L和/或Z和/或MZ的补充剂的摄入量作为补充剂使用情况。确定了四组：第1组（n = 24）：患有AMD且正确知晓；第2组（n = 264）：患有AMD但未意识到；第3组（n = 41）：未患AMD但错误地认为自己患有该病；第4组（n = 4094）：未患AMD且正确自我报告未患AMD。

结果

在4423名有血浆L和Z浓度及可分级视网膜照片的参与者中，288人（6.5%）患有AMD，65人（1.5%）自我报告患有AMD。在控制家族史和年龄后，经分级确认的AMD与血浆L之间的关系呈正相关且具有显著性（p < 0.001）。第2组（均值 = 0.2162 ± 0.132 µmol）和第4组（均值 = 0.2040 ± 0.121 µmol/L）的血浆L平均浓度显著低于第1组（均值 = 0.4691 ± 0.0.372 µmol/L）和第3组（均值 = 0.3176 ± 0.0.235 µmol/L）。第1组和第3组分别有41.7%和17.1%的参与者报告使用了补充剂，但第2组和第4组分别只有2.7%和1.9%的参与者使用了补充剂。