Dasch Burkhard, Fuhs Andrea, Schmidt Joachim, Behrens Thomas, Meister Astrid, Wellmann Juergen, Fobker Manfred, Pauleikhoff Daniel, Hense Hans-Werner
Institute of Epidemiology and Social Medicine, University of Muenster, Domagkstrasse 3, 48149, Muenster, Germany.
Graefes Arch Clin Exp Ophthalmol. 2005 Oct;243(10):1028-35. doi: 10.1007/s00417-005-1176-z. Epub 2005 Oct 20.
It has been hypothesized that the macular carotenoids, lutein and zeaxanthin, may protect against age-related maculopathy. We evaluated the association between blood concentrations of lutein (L) and zeaxanthin (Z) and age-related maculopathy (ARM) in a case-control analysis of the baseline examination of the Muenster Ageing and Retina Study (MARS).
Of the 1060 participants aged 59-82 years at baseline, 910 (85.9%) with bilateral gradable fundus photographs and complete data for the carotenoids and potential confounders were included. The Rotterdam classification system was used for definition of ARM stages. Multivariate linear regression methods were applied to model the relationship between macular carotenoids and the presence of ARM.
The participants' mean age was 70.9+5.5 years, 59.9% were female, 20.8% had a normal bilateral fundus, and 48.5% showed signs of early ARM (uni- or bilateral) and 30.7% of late ARM (in at least one eye). In study participants with L and/or Z supplementation (15.6%), the median serum levels for L (Z) were approximately 2 times (1.5 times) higher than in subjects with no supplementation. After exclusion of subjects with L and/or Z supplementation, no statistically significant bivariate relationship was observed between the serum levels of L or Z and the presence of ARM. Multivariate regression models, adjusting for age, gender, smoking, body-mass index, and HDL-cholesterol blood levels, produced adjusted mean serum levels of 0.124, 0.112, and 0.131 microg/ml for L and 0.019, 0.020, and 0.022 microg/ml for Z in subjects with normal fundus, early ARM, and late ARM, respectively.
In this large study, the serum concentrations of L and Z were not related to the prevalence of ARM. However, the large proportion of study participants taking L and/or Z supplementation may have affected these results.
据推测，黄斑类胡萝卜素，即叶黄素和玉米黄质，可能预防年龄相关性黄斑病变。在明斯特衰老与视网膜研究（MARS）基线检查的病例对照分析中，我们评估了叶黄素（L）和玉米黄质（Z）的血浓度与年龄相关性黄斑病变（ARM）之间的关联。
在基线时年龄为59 - 82岁的1060名参与者中，910名（85.9%）有可分级的双侧眼底照片以及类胡萝卜素和潜在混杂因素的完整数据，被纳入研究。采用鹿特丹分类系统定义ARM分期。应用多元线性回归方法建立黄斑类胡萝卜素与ARM存在情况之间的关系模型。
参与者的平均年龄为70.9±5.5岁，59.9%为女性，20.8%双侧眼底正常，48.5%有早期ARM迹象（单侧或双侧），30.7%有晚期ARM（至少一只眼）。在服用L和/或Z补充剂的研究参与者中（15.6%），L（Z）的血清中位数水平比未服用补充剂的受试者高约2倍（1.5倍）。排除服用L和/或Z补充剂的受试者后，未观察到L或Z的血清水平与ARM存在情况之间有统计学显著的双变量关系。在调整年龄、性别、吸烟、体重指数和高密度脂蛋白胆固醇血水平的多元回归模型中，眼底正常、早期ARM和晚期ARM受试者的L调整后平均血清水平分别为0.124、0.112和0.131微克/毫升，Z分别为0.019、0.020和0.022微克/毫升。
在这项大型研究中，L和Z的血清浓度与ARM患病率无关。然而，大量服用L和/或Z补充剂的研究参与者可能影响了这些结果。
