Tsuchida T, Saxton R E, Morton D L, Irie R F
Division of Surgical Oncology, John Wayne Clinic, UCLA School of Medicine 90024.
Cancer. 1989 Mar 15;63(6):1166-74. doi: 10.1002/1097-0142(19890315)63:6<1166::aid-cncr2820630621>3.0.co;2-5.
Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relationship between the quantity of five major gangliosides of human melanoma (GM3, GM2, GD3, GD2, and alkali-labile ganglioside) and nine clinical factors (sex, age, site, stage, tumor size, pigmentation, histopathologic type of primary tumor, chemosensitivity, and prognosis). Melanoma specimens studied were obtained from patients of our clinic and included 52 biopsy specimens and 28 cultured cell lines. Analysis of melanoma biopsy specimens have shown a differential ganglioside expression among different sites of tumor, pigmentation, and histopathologic types. Results of cultured melanoma cell lines differed from those of biopsy specimens, but ganglioside expression also differed among the site of tumor, tumor size, histopathologic types, and chemosensitivity. GM3 positively correlated with a good prognosis in both biopsy and cultured melanomas.
人类黑色素瘤会合成大量神经节苷脂，即含有唾液酸的糖鞘脂。作者之前已证明，神经节苷脂谱在个体黑色素瘤之间存在差异，且广泛异质性。在当前研究中，进行了一项回顾性研究，以比较人类黑色素瘤的五种主要神经节苷脂（GM3、GM2、GD3、GD2和碱不稳定神经节苷脂）的含量与九个临床因素（性别、年龄、部位、分期、肿瘤大小、色素沉着、原发肿瘤的组织病理学类型、化疗敏感性和预后）之间的关系。所研究的黑色素瘤标本取自我们诊所的患者，包括52份活检标本和28个培养细胞系。对黑色素瘤活检标本的分析表明，在肿瘤的不同部位、色素沉着和组织病理学类型之间，神经节苷脂表达存在差异。培养的黑色素瘤细胞系的结果与活检标本不同，但神经节苷脂表达在肿瘤部位、肿瘤大小、组织病理学类型和化疗敏感性之间也存在差异。在活检和培养的黑色素瘤中，GM3均与良好预后呈正相关。
